(3-氧代丙基)氨基甲酸叔丁酯合成路线 （共 15 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; sodium hydrogencarbonate; tetrabutyl-ammonium chloride; potassium carbonate in chloroform T=20°C; 2 h;
参考文献
Laboratoire L. Lafon
Patent: US6809096 B1, 2004 ;
Location in patent: Page column 7 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=-10°C; 0.166667 - 0.333333 h; 2: With potassium hydrogensulfate in tetrahydrofuran; diethyl ether; water 0.25 h;
参考文献
Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 20 ;
反应条件
acetic acid in water T=20°C; 4 h;
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Patinote, Cindy; Roscoe, Wendi A.; Karlik, Stephen J.; Pucci, Bernard
ChemMedChem, 2010 , vol. 5, # 12 p. 2057 - 2064
反应条件
sodium hydrogencarbonate; sodium thiosulfate in dichloromethane
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane T=-90 - -85°C; 0.75 h; Inert atmosphere; 2: With methanol in hexane; dichloromethane T=-85°C; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 49 p. 6603 - 6605
反应条件
Schwartz's reagent in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 51 p. 6880 - 6882
反应条件
1: 89 percent / triethylamine / CH2Cl2 / 21 h / 20 °C 2: dimethylsulfoxide; oxalyl chloride; triethylamine / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 7 p. 852 - 856
反应条件
triethylamine in dichloromethane; water; dimethyl sulfoxide
参考文献
US6884868 B1, ;
US 6884868 B1
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
1.1: N-methylmorpholine; isobutylchloroformate / CH2Cl2 / 0.25 h / -15 °C 1.2: 100 percent / CH2Cl2 / 16 h / -15 - 20 °C 2.1: 64 percent / LiAlH4 / tetrahydrofuran / 0.33 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 9 p. 1719 - 1737
