外消旋4-[4-(环氧乙烷基甲氧基)-1,2,5-噻二唑-3-基]吗啉合成路线 （共 6 条）
反应条件
1: acetic acid / (S,S)-salen-cobalt(II) / tetrahydrofuran; H2O / 8 h / 0 - 20 °C 2: 66 percent / KI / 72 h / Heating View Scheme
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
反应条件
potassium iodide 72 h; Heating; Title compound not separated from byproducts;
参考文献
Tosi, Giovanni; Zironi, Federica; Caselli, Emilia; Forni, Arrigo; Prati, Fabio
Synthesis, 2004 , # 10 p. 1625 - 1628
反应条件
1: acetic acid / (S,S)-salen-cobalt(II) / tetrahydrofuran; H2O / 8 h / 0 - 20 °C 2: 66 percent / KI / 72 h / Heating 3: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
反应条件
potassium tert-butylate in tetrahydrofuran
T=25°C; 5 h;
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
McClure,D.E. et al.
Journal of Organic Chemistry, 1979 , vol. 44, p. 1826 - 1831
反应条件
1: potassium hydroxide / water; dimethyl sulfoxide / |Reflux
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
View Scheme
参考文献
Kong, Xu-Dong; Ma, Qian; Zhou, Jiahai; Zeng, Bu-Bing; Xu, Jian-He
Angewandte Chemie - International Edition, 2014 , vol. 53, # 26 p. 6641 - 6644
Angew. Chem., 2014 , p. 6759 - 6762,4
