1-碘-3,4-亚甲基二氧基苯合成路线 （共 31 条）
反应条件
N-iodo-succinimide in various solvent(s) T=27°C; 0.416667 h;
参考文献
Yadav; Reddy; Basak; Narsaiah
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 1 p. 77 - 82
反应条件
n-butyllithium; iodine in tetrahydrofuran; hexane 1.) -90 to -50 deg C, 15 min, 2.) -78 deg C to r.t.;
参考文献
Pearson; Postich
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5662 - 5671
参考文献
Ortho Pharmaceutical Corporation
Patent: US4761413 A1, 1988 ;
US 4761413 A
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: 4,5-dihydro-5-(iodomethyl)furan-2(3H)-pne T=-78°C; 1.5 h;
参考文献
Harrowven, David C; Nunn, Michael I.T; Fenwick, David R
Tetrahedron Letters, 2001 , vol. 42, # 42 p. 7501 - 7502
反应条件
1: With hydrogenchloride; sodium nitrite 0.416667 h; cooling; 2: With urea; potassium iodide
参考文献
He, Huazhong; Zatorska, Danuta; Kim, Joungnam; Aguirre, Julia; Llauger, Laura; She, Yuhong; Wu, Nian; Immormino, Robert M.; Gewirth, Daniel T.; Chiosis, Gabriela
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 381 - 390
反应条件
tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=25 - 150°C; Heck reaction; 0.0916667 h; Microwave irradiation;
参考文献
Amaral, Patricia A.; Gouault, Nicolas; Roch, Myriam Le; Eifler-Lima, Vera L.; David, Michele
Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6607 - 6609
反应条件
triethylamine; 1,2-bis[(diphenylarsino)]ethane; palladium diacetate in 1,4-dioxane T=80°C; 24 h;
参考文献
Commonwealth Scientific and Industrial Research Organisation
Patent: US6680401 B1, 2004 ;
Location in patent: Page column 26 ;
反应条件
tetraethylammonium p-toluenesulfonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide Pt anode/Pt cathode; electrolysis with 2.5 mA/cm2;
参考文献
Chemistry Letters, , p. 169 - 172
反应条件
1: 99 percent / P-ph-phen*Pd(0), NaOAc / dimethylformamide; H2O / 12 h / 130 °C 2: H2 / 5percent Pd/C / ethanol / 8 h / 100 °C / 3040 Torr View Scheme
参考文献
Zhuangyu, Zhang; Yi, Pan; Hongwen, Hu; Tsi-yu, Kao
Synthetic Communications, 1990 , vol. 20, # 22 p. 3563 - 3574
反应条件
potassium carbonate; palladium monocarbide in methanol
参考文献
Commonwealth Scientific and Industrial Research Organization
Patent: US6448433 B1, 2002 ;
