4-溴-4′-甲氧基联苯合成路线 （共 57 条）
反应条件
potassium carbonate; palladium dichloride in ethanol; water T=20°C; Suzuki cross-coupling; 0.5 h;
参考文献
Qiu, Jun; Wang, Limin; Liu, Mingtao; Shen, Qiang; Tang, Jun
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6489 - 6491
反应条件
tetrakis(triphenylphosphine) palladium(0); caesium carbonate in methanol; toluene Suzuki-Miyaura cross coupling; 12 h; RefluxInert atmosphere; regiospecific reaction;
参考文献
Guillen, Elena; Hierrezuelo, Jesus; Martinez-Mallorquin, Rocio; Lopez-Romero, J. Manuel; Rico, Rodrigo
Tetrahedron, 2011 , vol. 67, # 14 p. 2555 - 2561
反应条件
1: 4-bromo-4'-hydroxybiphenyl With sodium hydride in N,N-dimethyl-formamide T=25 - 50°C; 2: methyl iodide in N,N-dimethyl-formamide T=30°C; 2 h; Further stages.;
参考文献
Katagiri, Toshifumi; Ota, Satoshi; Ohira, Takayuki; Yamao, Takeshi; Hotta, Shu
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 4 p. 853 - 862
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium lauryl sulfate; potassium carbonate; p-toluenesulfonyl chloride in water T=60°C; Suzuki Coupling;
参考文献
Liu, Jin-Biao; Zhou, He-Ping; Peng, Yi-Yuan
Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2872 - 2875
反应条件
lithium hydroxide in tetrahydrofuran T=70°C; Methylation; 1 h;
参考文献
Spivey, Alan C.; Diaper, Christopher M.; Adams, Harry; Rudge, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5253 - 5263
反应条件
1: 4-bromo-aniline With tert.-butylnitrite; boron trifluoride diethyl etherate in methanol T=0°C; 0.5 h; Schlenk technique; 2: (4-methoxyphenyl)-boronic acid in methanol T=0 - 60°C; 5 h; Schlenk technique;
参考文献
Zong, Yan; Hu, Jiefeng; Sun, Peipei; Jiang, Xiaoqing
Synlett, 2012 , vol. 23, # 16 art. no. ST-2012-W0506-L, p. 2393 - 2396
反应条件
tetrakis(triphenylphosphine) palladium(0); silver(l) oxide in tetrahydrofuran T=60°C; Arylation; 36 h;
参考文献
Hirabayashi, Kazunori; Kawashima, Jun; Nishihara, Yasushi; Mori, Atsunori; Hiyama, Tamejiro
Organic Letters, 1999 , vol. 1, # 2 p. 299 - 301
反应条件
potassium fluoride; palladium diacetate in toluene T=80°C; Suzuki-Miyaura coupling; 3.5 h;
参考文献
Suzuki, Ken; Fontaine, Arnaud; Hori, Yoji; Kobayashi, Tohru
Synlett, 2007 , # 20 p. 3206 - 3208
反应条件
1 Pd/C in methanol T=50°C; Suzuki-Miyaura reaction; 0.25 h; Inert atmosphere;
参考文献
Bonin, Helene; Delbrayelle, Dominique; Demonchaux, Patrice; Gras, Emmanuel
Chemical Communications, 2010 , vol. 46, # 15 p. 2677 - 2679
反应条件
palladium diacetate; SIDip*HCl in 1,4-dioxane T=100°C; P=760 Torr; 5 h;
参考文献
Tetrahedron Letters, , vol. 43, # 50 p. 9137 - 9140
