4-甲氧基-4’-氰基联苯合成路线 （共 80 条）
反应条件
potassium carbonate; palladium dichloride in ethanol; water T=20°C; Suzuki cross-coupling; 0.0833333 h;
参考文献
Tetrahedron Letters, , vol. 52, # 48 p. 6489 - 6491
反应条件
DTBPPS; palladium diacetate; sodium carbonate in water; acetonitrile T=23°C; Suzuki coupling; Inert atmosphere;
参考文献
Du, Zhengyin; Zhou, Wanwei; Wang, Fen; Wang, Jin-Xian
Tetrahedron, 2011 , vol. 67, # 26 p. 4914 - 4918
反应条件
1: 4-methoxyphenyl magnesium bromide With zinc dibromide in tetrahydrofuran; ethylpyrrolidin-2-one; 1- Inert atmosphereSchlenk tubeCooling; 2: para-bromobenzonitrile With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1- T=50°C; 72 h; Schlenk tubeInert atmosphere; 3: With ammonium chloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1-
参考文献
US2010/184977 A1, ;
Page/Page column 7-8 ;
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Shui-Ming; Zhou, Yi-Guo; Sun, Feng-Yi; Gao, Lian-Xun; Han, Fu-She
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1543 - 1550
反应条件
potassium carbonate in acetone T=20°C; 23 h;
参考文献
WYETH
Patent: WO2005/30702 A1, 2005 ;
Location in patent: Page/Page column 47 ;
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tert.-butylnitrite; trifuran-2-yl-phosphane; acetic acid in N,N-dimethyl-formamide T=90°C; 8 h; Inert atmosphere;
参考文献
Mo, Fanyang; Qiu, Di; Jiang, Yubo; Zhang, Yan; Wang, Jianbo
Tetrahedron Letters, 2011 , vol. 52, # 4 p. 518 - 522
反应条件
NHC-Pd(II)-Im; tetrabutyl ammonium fluoride in toluene T=120°C; Hiyama reaction; 3 h; Inert atmosphere;
参考文献
Gu, Zheng-Song; Shao, Li-Xiong; Lu, Jian-Mei
Journal of Organometallic Chemistry, 2012 , vol. 700, p. 132 - 134
反应条件
potassium phosphate in carbonic acid dimethyl ester T=135°C; Inert atmosphere;
参考文献
Inamoto, Kiyofumi; Hasegawa, Chisa; Hiroya, Kou; Kondo, Yoshinori; Osako, Takao; Uozumi, Yasuhiro; Doi, Takayuki
Chemical Communications, 2012 , vol. 48, # 23 p. 2912 - 2914
反应条件
Pd-PEPPSI-IPr in tetrahydrofuran T=25°C; Negishi Coupling Reaction; 2 h;
参考文献
WO2012/85168 A1, ;
Page/Page column 28; 31 ;
反应条件
1: para-bromobenzonitrile With cobalt(II) dibromide; zinc dibromide; zinc; bromobenzene; trifluoroacetic acid in acetonitrile T=20°C; 0.5 h; 2: para-iodoanisole With bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=20°C;
参考文献
Journal of the American Chemical Society, , vol. 125, # 13 p. 3867 - 3870
