N-苯甲酰基-l-脯氨酸合成路线 （共 24 条）
反应条件
(NH4)2S2O8; silver nitrate in water T=20°C;
参考文献
Huang, Wenhua; Wang, Meiling; Yue, Hong
Synthesis, 2008 , # 9 art. no. F23807SS, p. 1342 - 1344
反应条件
2,6-dichloropyridine-N-oxide; dichloro(5,10,15,20-tetramesitylporphyrinato)ruthenium(IV) in benzene T=40°C;
参考文献
Ito, Rina; Umezawa, Naoki; Higuchi, Tsunehiko
Journal of the American Chemical Society, 2005 , vol. 127, # 3 p. 834 - 835
反应条件
1: 96 percent / thionyl chloride / 1.) 0 deg C, 1 h, 2.) RT, overnight 2: 1.) LDA, N,N,N',N'-tetramethylenediamine / 1.) THF, hexanes, -75 deg C, 10 min, 2.) a.) -78 deg C, 1 h, b.) from -78 deg C to 0 deg C 3: H2 / Raney nickel / methanol; tetrahydrofuran / 46 h / 50 °C / 2585.7 Torr 4: toluene / 48 h / Heating View Scheme
参考文献
Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275
反应条件
1: 96 percent / thionyl chloride / 1.) 0 deg C, 1 h, 2.) RT, overnight 2: 1.) LDA, N,N,N',N'-tetramethylenediamine / 1.) THF, hexanes, -75 deg C, 10 min, 2.) a.) -78 deg C, 1 h, b.) from -78 deg C to 0 deg C 3: H2 / Raney nickel / methanol; tetrahydrofuran / 46 h / 50 °C / 2585.7 Torr 4: toluene / 48 h / Heating 5: lithium aluminum hydride / tetrahydrofuran / 1.) RT, 2 d, 2.) reflux, 2 h View Scheme
参考文献
Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) 0 deg C, 1 h, 2.) reflux, 16 h;
参考文献
Deur, Christopher J.; Miller, Michael W.; Hegedus, Louis S.
Journal of Organic Chemistry, 1996 , vol. 61, # 8 p. 2871 - 2876
反应条件
hydrogen; palladium on activated charcoal in methanol
P=1551.4 Torr; 3 h;
参考文献
Abraham; Gazze; Kennedy; Mokotoff
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559
反应条件
sodium hydroxide in tetrahydrofuran
T=0 - 20°C;
参考文献
Bonsignore, Martina; Benaglia, Maurizio; Raimondi, Laura; Orlandi, Manuel; Celentano, Giuseppe
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 633 - 640
反应条件
1: N,N-diisopropylethylamine
2: H2
View Scheme
参考文献
Ishitani, Hitoshi; Achiwa, Kazuo
Heterocycles, 1997 , vol. 46, # 1 p. 153 - 156
反应条件
1: 73 percent / DMAP, DCC / CH2Cl2 / Ambient temperature
2: 83 percent / H2 / 10percent Pd/C / methanol / 3 h / 1551.4 Torr
View Scheme
参考文献
Abraham; Gazze; Kennedy; Mokotoff
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559
反应条件
1: pyridine / CH2Cl2 / 3 h / 25 °C
2: H2 / 10percent Pd/C / ethanol / 3102.9 Torr
View Scheme
参考文献
Pfeiffer; Chambers; Hilbert; Woodward; Ackerman
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 325 - 341
