5,7-二甲基吡唑并嘧啶-2-羧酸合成路线 （共 12 条）
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran
16 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia
Patent: EP2292587 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With sodium hydroxide in water
T=0 - 20°C; 6 h;
2: With hydrogenchloride in water
pH=1;
参考文献
Mitsui Chemicals, Inc.
Patent: EP1938685 A1, 2008 ;
Location in patent: Page/Page column 143 ;
反应条件
potassium permanganate in water
1.5 h; Heating;
参考文献
Lee, Chang Kiu; Ahn, Yu Mi
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3744 - 3747
反应条件
1: thionyl chloride / 16 h / 0 °C
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h
3: water; lithium hydroxide hydrate / tetrahydrofuran / 16 h
View Scheme
参考文献
Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia
Patent: EP2292587 A1, 2011 ;
反应条件
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h
2: water; lithium hydroxide hydrate / tetrahydrofuran / 16 h
View Scheme
参考文献
Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia
Patent: EP2292587 A1, 2011 ;
参考文献
Pellizzari
Gazzetta Chimica Italiana, 1885 , vol. 15, p. 567
Justus Liebigs Annalen der Chemie, 1886 , vol. 232, p. 153
参考文献
Pellizzari
Gazzetta Chimica Italiana, 1885 , vol. 15, p. 567
Justus Liebigs Annalen der Chemie, 1886 , vol. 232, p. 153
参考文献
Cahours
Justus Liebigs Annalen der Chemie, 1857 , vol. 103, p. 90
参考文献
Mejer et al.
Roczniki Chemii, 1958 , vol. 32, p. 277,279, 280
Chem.Abstr., 1958 , p. 19893
参考文献
Heller; Tischner
Chemische Berichte, 1910 , vol. 43, p. 2578
