反式 环丙烷-1,2-二羧酸合成路线 （共 33 条）
反应条件
ethanol; sulfuric acid; toluene
参考文献
Wiberg et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 4994,4997
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Blomquist; Longone
Journal of the American Chemical Society, 1959 , vol. 81, p. 2012,2015
反应条件
bromine; mercury(II) oxide in tetrachloromethane; dichloromethane
参考文献
Hammerschmidt,F.; Zbiral,E.
Monatshefte fuer Chemie, 1977 , vol. 108, p. 1253 - 1263
参考文献
Schneider, Manfred; Engel, Norbert; Hoenicke, Petra; Heinemann, Gerd; Goerisch, Helmut
Angewandte Chemie, 1984 , vol. 96, # 1 p. 55 - 56
反应条件
acetic anhydride T=200°C; bei Erhitzen im geschlossenen Rohr;
参考文献
Journal of the Chemical Society, , vol. 83, p. 784
反应条件
1: ethanol; toluene; H2SO4 2: aq.-ethanolic NaOH View Scheme
参考文献
Wiberg et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 4994,4997
反应条件
sodium azide; phosphorus pentachloride in toluene Curtius reaction; 32 h;
参考文献
Yang, Donglai; Kefi, Slaheddine; Audinot, Valerie; Millan, Mark-J.; Langlois, Michel
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 2 p. 321 - 327
反应条件
sodium hydroxide; water in ethanol
T=20°C; Hydrolysis; 3 h;
参考文献
Khalaf, Abedawn I.; Pitt, Andrew R.; Scobie, Martin; Suckling, Colin J.; Urwin, John; Waigh, Roger D.; Fishleigh, Robert V.; Young, Steven C.; Wylie, William A.
Tetrahedron, 2000 , vol. 56, # 29 p. 5225 - 5239
反应条件
sodium hydroxide
Hydrolysis; 1) reflux, 1 h, 2) r.t., overnight;
参考文献
Tao, Bin; Huang, Tien L; Zhang, Qian; Jackson, Latasha; Queener, Sherry F.; Donkor, Isaac O.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 6 p. 531 - 538
反应条件
potassium tert-butylate; chloroacetic acid ethyl ester
Hydrolysieren des erhaltenen Reaktionsprodukts;
参考文献
Mousseron et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959 , vol. 248, p. 1465
反应条件
sodium methylate; chloroacetic acid ethyl ester
Hydrolysieren des erhaltenen Reaktionsprodukts;
参考文献
McCoy
Journal of the American Chemical Society, 1958 , vol. 80, p. 6568,6572
