(R)-(+)-2-氨基-3-苄氧基-1-丙醇合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride
参考文献
Danklmaier, Johann; Hoenig, Helmut
Liebigs Annalen der Chemie, 1988 , p. 851 - 854
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=0°C; 1 h; 2: With sodium hydroxide; water in diethyl ether; ethyl acetate 0.5 h;
参考文献
WO2006/83440 A2, ;
Page/Page column 142 ;
反应条件
potassium hydroxide; ammonium hydroxide in tetrahydrofuran; diethyl ether; chloroform; water
反应条件
potassium hydroxide; sodium tetrahydroborate; I2 in tetrahydrofuran; chloroform; water
反应条件
sodium tetrahydroborate in ethanol
参考文献
Berkowitz, David B.; Shen, Quanrong; Maeng, Jun-Ho
Tetrahedron Letters, 1994 , vol. 35, # 35 p. 6445 - 6448
反应条件
1: 100 percent 2: 100 percent / trifluoroacetic acid / CH2Cl2 3: 61 percent / NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 35 p. 6445 - 6448
反应条件
1: 100 percent / trifluoroacetic acid / CH2Cl2 2: 61 percent / NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 35 p. 6445 - 6448
反应条件
sodium tetrahydroborate; sulfuric acid
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 15 p. 2273 - 2278
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (R)-2-amino-3-benzyloxy-1-propanol With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
