N-(叔丁氧基羰基)-L-缬氨酸甲酯合成路线 （共 63 条）
反应条件
1: 85 percent / DMAP / acetonitrile / 20 °C 2: 40 percent / acetonitrile / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1480 - 1485
反应条件
1: trifluoroacetic acid 2: H2; Raney Ni 3: 4-dimethylaminopyridine View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 10 p. 1790 - 1793
反应条件
1: KMnO4 2: trifluoroacetic acid 3: H2; Raney Ni 4: 4-dimethylaminopyridine View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 10 p. 1790 - 1793
反应条件
4-(N,N-dimethlyamino)pyridine Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 10 p. 1790 - 1793
反应条件
1: 81 percent / DCC; HOBt / dimethylformamide 2: 85 percent / DMAP / acetonitrile / 20 °C 3: 40 percent / acetonitrile / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1480 - 1485
反应条件
1: (2R,5S,3E)-2-(Benzyloxymethoxy)-6-methyl-5-(tert-butoxycarbonylamino)hept-3-ene With ozone in methanol T=-78°C; Oxidation; Ozonolysis; 0.333333 h; 2: With dimethylsulfide in methanol T=-78 - 20°C; Reduction; 1 h; 3: methanol With water; bromine; sodium hydrogencarbonate T=20°C; Oxidation; Esterification; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 22 p. 3291 - 3303
反应条件
1: 81 percent / DCC; HOBt / dimethylformamide 2: 85 percent / DMAP / acetonitrile 3: 40 percent / acetonitrile / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 44 p. 7775 - 7777
反应条件
1: 62 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 45 min, 2.) -78 deg C, 1 h 2: 1.) 0.25 M HCl, 2.) Et3N / 1.) THF, r.t., 90 min, 2.) DMF, 60 deg C, 30 min View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 2 p. 218 - 221
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine 1.) CH2Cl2, 0 deg C, 10 min, 2.) 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 50, # 5 p. 560 - 565
反应条件
4-(N,N-dimethlyamino)pyridine; hydrazine 1.) THF, reflux, 4 h, 2.) MeOH, room temperature, 4 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 62, # 20 p. 7054 - 7057
