N-(叔丁氧基羰基)-L-缬氨酸甲酯合成路线 （共 63 条）
反应条件
1: (2R,5S)-5-isopropyl-3,6-dimethoxy-2-(1-methyldeca-2,3-dien-4-yl)-2,5-dihydropyrazine With water; trifluoroacetic acid in tetrahydrofuran T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 12 h; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 21 p. 3605 - 3612
反应条件
1: (2R,5S)-5-isopropyl-3,6-dimethoxy-2-(1-methylocta-2,3-dien-4-yl)-2,5-dihydropyrazine With water; trifluoroacetic acid in tetrahydrofuran T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 12 h; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 21 p. 3605 - 3612
反应条件
1: (2R,5S)-2-(hepta-1,2-dien-3-yl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine With water; trifluoroacetic acid in tetrahydrofuran T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 12 h; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 21 p. 3605 - 3612
反应条件
1: AcCl / Heating 2: Et3N / CH2Cl2 View Scheme
参考文献
Synlett, , # 15 p. 2815 - 2817
反应条件
1.1: NaBH4 / dimethylformamide / 20 °C 1.2: 62 percent / dimethylformamide / 4 h / 120 °C 2.1: tetrahydrofuran / 1 h / 0 °C 3.1: 6.68 g / tetrahydrofuran / 3.5 h / -78 - 20 °C 4.1: KHMDS / tetrahydrofuran / 0.67 h / -78 °C 4.2: 80 percent / trisyl azide; KOAc; AcOH / tetrahydrofuran / -78 - 20 °C 5.1: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C 6.1: SnCl2 / dioxane; H2O / 7 h / 0 - 20 °C 7.1: aq. NaOH / 1 h / 20 °C 8.1: 95 percent / diethyl ether 9.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 9.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 10.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: aq. NaOH / 1 h / 20 °C 2.1: 95 percent / diethyl ether 3.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 3.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 4.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: tetrahydrofuran / 1 h / 0 °C 2.1: 6.68 g / tetrahydrofuran / 3.5 h / -78 - 20 °C 3.1: KHMDS / tetrahydrofuran / 0.67 h / -78 °C 3.2: 80 percent / trisyl azide; KOAc; AcOH / tetrahydrofuran / -78 - 20 °C 4.1: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C 5.1: SnCl2 / dioxane; H2O / 7 h / 0 - 20 °C 6.1: aq. NaOH / 1 h / 20 °C 7.1: 95 percent / diethyl ether 8.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 8.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 9.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: SnCl2 / dioxane; H2O / 7 h / 0 - 20 °C 2.1: aq. NaOH / 1 h / 20 °C 3.1: 95 percent / diethyl ether 4.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 4.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 5.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 1.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 2.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: 95 percent / diethyl ether 2.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 2.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 3.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
