1: With tetrabutylammomium bromide; potassium carbonate in 1-methyl-pyrrolidin-2-one T=60 - 65°C; 16 h; 2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water pH=~ 4;
参考文献
ASTRAZENECA AB
Patent: WO2009/11655 A1, 2009 ;
Location in patent: Page/Page column 38 ;
WO 2009/011655 A1