CjNCS2 in acetonitrile T=37°C; pH=7.4; 3 h; Enzymatic reaction;

boron tribromide in dichloromethane T=-78 - 20°C; 2 h; Overall yield = 78 percent; Overall yield = 38 mg;

1.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 2.1: 4-(N,N-dimethlyamino)pyridine; boron trifluoride diethyl etherate; B2H6*Me2S / 3 h / 70 °C 3.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 4.1: trichlorophosphate / benzene / 7 h / |Reflux 4.2: 3 h / 20 °C / |Inert atmosphere 5.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; boron trifluoride diethyl etherate; B2H6*Me2S / 3 h / 70 °C 2.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 3.1: trichlorophosphate / benzene / 7 h / |Reflux 3.2: 3 h / 20 °C / |Inert atmosphere 4.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme

1.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 2.1: trichlorophosphate / benzene / 7 h / |Reflux 2.2: 3 h / 20 °C / |Inert atmosphere 3.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme

1.1: trichlorophosphate / benzene / 7 h / |Reflux 1.2: 3 h / 20 °C / |Inert atmosphere 2.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme