2-烯丙基-4-甲氧基苯酚合成路线 （共 28 条）
反应条件
1.1: triethylamine / CH2Cl2 / 0 - 20 °C 2.1: OsO4; NaIO4 / diethyl ether; acetone; H2O / 8 h 2.2: sodium borohydride / methanol / 0.5 h / 0 °C 3.1: 0.183 g / tetra-n-butylammonium fluoride / CH2Cl2; tetrahydrofuran / 1 h / 0 - 20 °C 4.1: 96 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.08 h 5.1: 79 percent / pyridinium p-toluenesulfonate; dihydro-1,4-benzoquinone / toluene / 3 h / Heating View Scheme
参考文献
Benbow; Katoch-Rouse
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 4965 - 4972
反应条件
1.1: O3 / CH2Cl2 / 0.5 h / 0 °C 1.2: 0.31 g / PPh3 / CH2Cl2 / 2.25 h / 0 - 20 °C View Scheme
参考文献
Harmata; Wu; Kahraman; Welch
Synthetic Communications, 2001 , vol. 31, # 21 p. 3345 - 3359
反应条件
air; water; potassium hydrogencarbonate; bis(dibenzylideneacetone)-palladium(0) in dimethyl sulfoxide T=60°C; 72 h;
参考文献
Larock, Richard C.; Wei, Lulin; Hightower, Timothy R.
Synlett, 1998 , # 5 p. 522 - 524
反应条件
1.1: sodium tetrahydroborate; dimethyl sulfate / tetrahydrofuran / 1 h / 20 °C 1.2: 2 h / 20 °C 2.1: hydrogen bromide / water / 3 h / |Reflux View Scheme
参考文献
Yagunov; Khol'shin; Kandalintseva; Prosenko
Russian Chemical Bulletin, 2013 , vol. 62, # 6 p. 1395 - 1400
Izv. Akad. Nauk, Ser. Khim., 2013 , # 6 p. 1395 - 1400,6
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=760 Torr; Ambient temperature;
参考文献
Hong, Fang-Tsao; Lee, Kung-Shing; Tsai, Yow-Fu; Liao, Chun-Chen
Journal of the Chinese Chemical Society, 1998 , vol. 45, # 1 p. 1 - 12
反应条件
1: 82 percent / aq. NaOH; tetrabutylammonium bromide / 4 h / Heating 2: 89 percent / KO-t-Bu / tetrahydrofuran / 0.5 h / Heating 3: 75 percent / Grubbs catalyst / CH2Cl2 / 8 h / 20 °C View Scheme
参考文献
Tsai, Tzu-Wei; Wang, Eng-Chi; Li, Sie-Rong; Chen, Yung-Hua; Lin, Yu-Li; Wang, You-Feng; Huang, Keng-Shiang
Journal of the Chinese Chemical Society, 2004 , vol. 51, # 6 p. 1307 - 1318
反应条件
1: With sodium tetrahydroborate; dimethyl sulfate in tetrahydrofuran T=20°C; 1 h; 2: With dihydrogen peroxide; sodium hydroxide in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Yagunov; Khol'shin; Kandalintseva; Prosenko
Russian Chemical Bulletin, 2013 , vol. 62, # 6 p. 1395 - 1400
Izv. Akad. Nauk, Ser. Khim., 2013 , # 6 p. 1395 - 1400,6
反应条件
1: K2CO3 / acetone / Heating 2: 1.) OsO4, 2.) sodium metaperiodate / 1.) THF, water, 0 deg C, 1 h, 2.) 0 deg C, 0.5 h; room temperature, 3 h View Scheme
参考文献
Deshmukh, M. N.; Joshi, Shreerang V.
Synthetic Communications, 1988 , vol. 18, # 13 p. 1483 - 1490
反应条件
1.1: potassium carbonate / acetone / 6 h / Reflux 2.1: 9-borabicyclo-[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C 2.2: 6 h / Reflux 3.1: pyridinium chlorochromate / dichloromethane / 5 h / 0 - 20 °C / Molecular sieve View Scheme
参考文献
UNIVERSITY OF NOTTINGHAM; BAKER, Jillian G.; FISCHER, Peter M.; FROMONT, Christophe; GARDINER, Sheila M.; HILL, Stephen J.; JADHAV, Gopal; KELLAM, Barrie; MISTRY, Shailesh; WOOLARD, Jeanette
Patent: WO2012/104659 A1, 2012 ;
WO 2012/104659 A1
反应条件
T=200°C; Claisen Rearrangement; 16 h; Inert atmosphere;
参考文献
UNIVERSITY OF NOTTINGHAM; BAKER, Jillian G.; FISCHER, Peter M.; FROMONT, Christophe; GARDINER, Sheila M.; HILL, Stephen J.; JADHAV, Gopal; KELLAM, Barrie; MISTRY, Shailesh; WOOLARD, Jeanette
Patent: WO2012/104659 A1, 2012 ;
Location in patent: Page/Page column 52; 53 ;
WO 2012/104659 A1
