4-溴-2-氯-6-硝基苯酚合成路线 （共 16 条）
参考文献
Ling
Journal of the Chemical Society, 1889 , vol. 55, p. 585,587
参考文献
Ling
Journal of the Chemical Society, 1889 , vol. 55, p. 585,587
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C 2: acetic acid; zinc / 12 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 24 p. 8616 - 8631
反应条件
sulfuric acid; nitric acid; sodium nitrite in water; propionic acid
T=30°C; 3.166 h; Product distribution / selectivity;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/77961 A2, 2007 ;
Location in patent: Page/Page column 309-310 ;
WO 2007/077961 A2
反应条件
(PhCH2PPh3)(+)Br3(-); calcium carbonate in methanol; dichloromethane
T=20°C; 7 h;
参考文献
Hajipour, Abdol R.; Pourmousavi, Seied A.; Ruoho, Arnold E.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 3 p. 796 - 800
反应条件
1: tetrachloromethane; bromine
2: glacial acetic acid; NaNO2
View Scheme
参考文献
Raiford; Miller
Journal of the American Chemical Society, 1933 , vol. 55, p. 2125,2129
反应条件
acetic acid; sodium nitrite
参考文献
Raiford; Miller
Journal of the American Chemical Society, 1933 , vol. 55, p. 2125,2129
反应条件
acetic acid; sodium nitrite
参考文献
Raiford; Miller
Journal of the American Chemical Society, 1933 , vol. 55, p. 2125,2129
反应条件
1: zinc dust; glacial acetic acid
2: durch Nitrierung
View Scheme
参考文献
Kohn; Sussmann
Monatshefte fuer Chemie, 1927 , vol. 48, p. 209
反应条件
1: glacial acetic acid; hydrobromic acid
2: durch Nitrierung
View Scheme
参考文献
Kohn; Sussmann
Monatshefte fuer Chemie, 1927 , vol. 48, p. 209
