5-氟-1,3-二氢-2H-苯并咪唑-2-硫酮合成路线 （共 6 条）
反应条件
in methanol T=20°C; 86.833 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
in ethanol 5 h; Heating / reflux;
参考文献
Kowa Co., Ltd.
Patent: US2005/20606 A1, 2005 ;
Location in patent: Page 10 ;
US 20050020606 A1
反应条件
1: nitric acid / 0 - 5 °C 2: 9 M HCl / 0.5 h / Heating 3: H2 / Raney Ni / ethanol 4: ethanol; H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: H2 / Raney Ni / ethanol 2: ethanol; H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 9 M HCl / 0.5 h / Heating 2: H2 / Raney Ni / ethanol 3: ethanol; H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 2 h / 110 °C 2: nitric acid / 0 - 5 °C 3: 9 M HCl / 0.5 h / Heating 4: H2 / Raney Ni / ethanol 5: ethanol; H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
