N,N-二乙基苯甲酰胺-4-羧醛合成路线 （共 14 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 37 percent / tetrahydrofuran; hexane / 1 h 2.1: SOCl2 / CH2Cl2 / 1 h / 25 °C View Scheme
参考文献
Zhang, Xiaoyan; Rice, Kenner C.; Calderon, Silvia N.; Kayakiri, Hiroshi; Smith, Larren; Coop, Andrew; Jacobson, Arthur E.; Rothman, Richard B.; Davis, Peg; Dersch, Christina M.; Porreca, Frank
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5455 - 5463
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.75 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.75 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.75 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.75 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=0 - 20°C; amidation; 4.5 h;
参考文献
Zhang, Xiaoyan; Rice, Kenner C.; Calderon, Silvia N.; Kayakiri, Hiroshi; Smith, Larren; Coop, Andrew; Jacobson, Arthur E.; Rothman, Richard B.; Davis, Peg; Dersch, Christina M.; Porreca, Frank
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5455 - 5463
反应条件
dimethyl sulfoxide; triethylamine in dichloromethane; water
参考文献
Tsushima, Masaki; Tadauchi, Kaori; Asai, Kenji; Miike, Naoko; Imai, Masako; Kudo, Toshiaki
Patent: US2003/171370 A1, 2003 ;
US 20030171370 A1
反应条件
hydrogenchloride in tetrahydrofuran; water; ethyl acetate
参考文献
Chang, Kwen-Jen; Pendergast, William; Gengo, Peter J.
Patent: US2003/144299 A1, 2003 ;
US 20030144299 A1
反应条件
1: SOCl2 / CH2Cl2; dimethylformamide / 50 °C
2: CH2Cl2; dimethylformamide / 0 °C
View Scheme
参考文献
Delorme, Daniel; Berthelette, Carl; Lavoie, Rico; Roberts, Edward
Tetrahedron Asymmetry, 1998 , vol. 9, # 22 p. 3963 - 3966
反应条件
in dichloromethane; N,N-dimethyl-formamide
T=0°C; Yield given;
参考文献
Delorme, Daniel; Berthelette, Carl; Lavoie, Rico; Roberts, Edward
Tetrahedron Asymmetry, 1998 , vol. 9, # 22 p. 3963 - 3966
