1: 4-formyl-benzoic acid With thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; Inert atmosphereReflux;
2: dimethyl amine in dichloromethane; water
1.25 h; Cooling with ice-water;
参考文献
LEAD THERAPEUTICS, INC.
Patent: US2010/35883 A1, 2010 ;
Location in patent: Page/Page column 80 ;