2,2-二甲基-5-己烯酸合成路线 （共 11 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3 h; 2: With sodium hydroxide; water in tetrahydrofuran T=0°C;
参考文献
Jandeleit, Bernd; Li, Yunxiao; Gallop, Mark A.; Zerangue, Noa; Virsik, Peter A.; Fischer, Wolf-Nicolas
Patent: US2009/69419 A1, 2009 ;
Location in patent: Page/Page column 54 ;
反应条件
1: LiAlH4 / diethyl ether / 0 °C 2: 6.6 g / Br2 / PPh3 / pyridine / 20 h / Heating 3: 7.5 percent Chromat. / LiAlH4 / tetrahydrofuran / 480 h / Ambient temperature View Scheme
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
反应条件
potassium hydroxide in tetrahydrofuran; methanol
T=25 - 40°C; 2 h;
参考文献
Pei, Tao; Wang, Xiang; Widenhoefer, Ross A.
Journal of the American Chemical Society, 2003 , vol. 125, # 3 p. 648 - 649
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water
T=40°C; 18 h;
参考文献
Mueller, I.-E. Sophie; Bernet, Bruno; Dengiz, Cagatay; Schweizer, W. Bernd; Diederich, Francois
European Journal of Organic Chemistry, 2014 , vol. 2014, # 5 p. 941 - 953
反应条件
1: HCl / 20 h / 0 °C
2: 1) Mg / THF
View Scheme
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
反应条件
magnesium
THF; Multistep reaction;
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
反应条件
Cu(I) salt; dimethylsulfide
1) THF; 2) -50 deg C, 1 h, -20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kawashima, Masatoshi; Sato, Toshio; Fujisawa, Tamotsu
Tetrahedron, 1989 , vol. 45, # 2 p. 403 - 412
反应条件
1: LiAlH4 / diethyl ether / 0 °C
2: 6.6 g / Br2 / PPh3 / pyridine / 20 h / Heating
3: 9.8 percent Chromat. / LiAlH4 / tetrahydrofuran / 480 h / Ambient temperature
View Scheme
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
反应条件
1: LiAlH4 / diethyl ether / 0 °C
2: 93 percent / I2 / PPh3 / pyridine / benzene / 24 h / Heating
View Scheme
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
反应条件
1: LiAlH4 / diethyl ether / 0 °C
2: 60 percent / pyridine / benzene / 24 h / Ambient temperature
View Scheme
参考文献
Ashby, E. C.; DePriest, R. N.; Goel, A. B.; Wenderoth, Bernd; Pham, Tung N.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3545 - 3556
