7-羟基-1,2,3,4-四氢喹啉合成路线 （共 20 条）
反应条件
phosphoric acid in water T=150°C; 14 h; Inert atmosphere;
参考文献
Boyarskiy, Vadim P.; Belov, Vladimir N.; Medda, Rebecca; Hein, Birka; Bossi, Mariano; Hell, Stefan W.
Chemistry - A European Journal, 2008 , vol. 14, # 6 p. 1784 - 1792
反应条件
bei der elektrochemischen Reduktion an Nickel-Kathoden;
参考文献
Helvetica Chimica Acta, , vol. 32, p. 1278,1281
反应条件
bei der elektrochemischen Reduktion an Blei-Kathoden;
参考文献
Helvetica Chimica Acta, , vol. 32, p. 1278,1281
参考文献
Atkins,R.L.; Bliss,D.E.
Journal of Organic Chemistry, 1978 , vol. 43, p. 1975 - 1980
反应条件
sodium hydrogencarbonate; tetrabutylammomium bromide in water
T=0 - 20°C; 12 h;
参考文献
UNIVERSITY OF MASSACHUSETTS
Patent: WO2009/36351 A2, 2009 ;
Location in patent: Page/Page column 13-14; 13/24 ;
反应条件
1: With sodium tetrahydroborate
T=20°C; 2 h; Inert atmosphere;
2: With acetaldehyde
T=20°C; Inert atmosphere;
参考文献
Anzalone, Andrew V.; Wang, Tracy Y.; Chen, Zhixing; Cornish, Virginia W.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 2 p. 650 - 654
Angew. Chem., 2013 , vol. 125, # 2 p. 678 - 682,5
反应条件
1: ZnCl2
2: 200 °C
View Scheme
参考文献
Atkins,R.L.; Bliss,D.E.
Journal of Organic Chemistry, 1978 , vol. 43, p. 1975 - 1980
反应条件
triethylamine in dichloromethane
T=45°C; 48 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/58867 A2, 2008 ;
Location in patent: Page/Page column 33-34 ;
WO 2008/058867 A2
参考文献
Haworth; Lamberton; Woodcock
Journal of the Chemical Society, 1947 , p. 179
反应条件
zinc(II) chloride in ethanol
T=110 - 120°C;
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
