(E)-3-(4-醛基苯基)丙烯酸甲酯合成路线 （共 12 条）
反应条件
polystyrene-supported palladacycle catalyst; sodium acetate in N,N-dimethyl acetamide T=100°C; Heck reaction; 10 h;
参考文献
Zhdanko, Alexander; Schmauder, Anke; Ma, Christopher I.; Sibley, L. David; Sept, David; Sasse, Florenz; Maier, Martin E.
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13349 - 13357
反应条件
hydrogenchloride 3 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/21682 A1, 2007 ;
Location in patent: Page/Page column 24-25 ;
反应条件
tetra-n-butylammonium acetate; palladium diacetate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine in 1,4-dioxane T=80°C; Heck reaction; 24 h; Inert atmosphereSealed tube;
参考文献
Xu, Hua-Jian; Zhao, Yong-Qiang; Zhou, Xin-Feng
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8036 - 8041
反应条件
potassium carbonate; dimethyl sulfate in N-methyl-acetamide
参考文献
Tsumura and Co.
Patent: US6413995 B1, 2002 ;
反应条件
triethylamine; lithium bromide in tetrahydrofuran T=5 - 25°C;
参考文献
WO2010/97586 A1, ;
Page/Page column 45 ;
WO 2010/097586 A1
反应条件
sodium acetate; 1H-tetrazole; palladium T=80°C; Heck reaction; 12 h;
参考文献
Gupta, Arun Kumar; Song, Chung Hyun; Oh, Chang Ho
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4113 - 4116
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Beecham Group p.l.c.
Patent: US4713486 A1, 1987 ;
反应条件
1: acrylic acid methyl ester; [4-iodophenyl]methanone With sodium hydrogencarbonate; N,N-dimethyl-formamide in water T=90°C; Heck reaction; 23 h; 2: methyl vinyl ketone With DL-proline in water T=40°C; Baylis-Hillman reaction; 22 h;
参考文献
Gruttadauria, Michelangelo; Bivona, Lucia Anna; Lo Meo, Paolo; Riela, Serena; Noto, Renato
European Journal of Organic Chemistry, 2012 , # 13 p. 2635 - 2642
反应条件
palladium diacetate; acetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone in acetic acid T=90°C; Heck reaction; 27 h;
参考文献
Sun, Peng; Zhu, Yan; Yang, Hailong; Yan, Hong; Lu, Linhua; Zhang, Xiang; Mao, Jincheng
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 23 p. 4512 - 4515
参考文献
Kryshtal, G. V.; Zhdankina, G. M.; Serebryakov, E. P.
Russian Chemical Bulletin, 1993 , vol. 42, # 5 p. 866 - 869
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 5 p. 910 - 913
