3,3’-双(三氟甲基)-1,1’-联苯合成路线 （共 42 条）
反应条件
1: m-trifluoro-methyl-phenyl-magnesium bromide With bismuth(III) chloride
2: 1-(5-bromo-thien-2-yl)ethanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide
T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: m-trifluoro-methyl-phenyl-magnesium bromide With bismuth(III) chloride
2: (5-iodo-2-thienyl)(phenyl)methanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide
T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1.1: 0.98 g / pyridine / 20 °C
2.1: t-BuLi; InCl3 / tetrahydrofuran; pentane / -78 - 20 °C
2.2: PPh3 / Pd2dba3 / tetrahydrofuran; pentane / Heating
View Scheme
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
1: With chloro-trimethyl-silane; ethylene dibromide; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium chloride; cobalt(II) chloride; zinc in tetrahydrofuran
T=80°C; 24 h; Inert atmosphere;
2: With iodine in tetrahydrofuran
0.5 h;
参考文献
Jin, Meng-Yi; Yoshikai, Naohiko
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 1972 - 1978
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene
T=100°C; 5 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene
T=100°C; 2 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene
T=80°C; 2 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene
T=100°C; 2 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid
T=90 - 150°C; 20 h;
参考文献
Zhou, Lihong; Lu, Wenjun
Organometallics, 2012 , vol. 31, # 6 p. 2124 - 2127
反应条件
Reaktion mit AgBr in Aether;
参考文献
Bradsher; Bond
Journal of the American Chemical Society, 1949 , vol. 71, p. 2659
