3,3’-双(三氟甲基)-1,1’-联苯合成路线 （共 42 条）
反应条件
sulfuric acid; nitric acid
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 1071,1073
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy in tetrahydrofuran
T=63°C; 0.1 h;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4840 - 4844
反应条件
1: 3-CF3C6H4MgX With indium(III) chloride in tetrahydrofuran
T=20°C; 1 h;
2: cyclohex-2-en-1-yl acetate With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran
Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
sec.-butyllithium; triethylamine; iron(II) chloride in tetrahydrofuran
T=-78 - 25°C; 4 h; Inert atmosphere;
参考文献
Toummini, Dounia; Ouazzani, Fouad; Taillefer, Marc
Organic Letters, 2013 , vol. 15, # 18 p. 4690 - 4693
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI in tetrahydrofuran
T=63°C; 0.7 h;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4840 - 4844
反应条件
bromobenzene; zinc dibromide; zinc; acetic acid; cobalt(II) dibromide in acetonitrile
T=20°C; 3 h;
参考文献
Perichon, Jacques; Gosmini, Corinne; Bastienne, Mylene; Gomes, Paulo
Patent: US2004/186328 A1, 2004 ;
Location in patent: Page 12-13 ;
反应条件
1: 1-bromo-3-trifluoromethyl-benzene With indium(III) chloride; tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - 20°C;
2: cyclohex-2-en-1-yl acetate With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran; pentane
Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
1: 3-CF3C6H4MgX With indium(III) chloride in tetrahydrofuran
T=20°C; 1 h;
2: 2-methyl-cyclohex-2-en-1-yl acetate With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran
Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; water; toluene
T=100°C; 12 h; Inert atmosphere;
参考文献
Zhang, Zun-Ting; Pitteloud, Jean-Philippe; Cabrera, Laura; Liang, Yong; Toribio, Myrdich; Wnuk, Stanislaw F.
Organic Letters, 2010 , vol. 12, # 4 p. 816 - 819
反应条件
1: 1-bromo-3-trifluoromethyl-benzene With indium(III) chloride; tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - 20°C;
2: 2-methyl-cyclohex-2-en-1-yl acetate With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran; pentane
Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
