反应条件
1: 89 percent / NaH / 20 °C
2: 72 percent / p-xylene / Heating
3: 92 percent / NaH / 20 °C
4: 88 percent / AD-mix-α / 2-methyl-propan-2-ol; H2O / 20 °C
5: 65 percent / HBr / 60 °C
6: 61 percent / NaH / dimethylformamide
7: 91 percent / K2CO3 / methanol / 20 °C
8: 93 percent / pyridine / 20 °C
9: 77 percent / NaN3 / dimethylformamide / 60 °C
10: 70 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
View Scheme
参考文献
Zhou, Dahui; Hatzenbuhler, Nicole T.; Gross, Jonathan L.; Harrison, Boyd L.; Evrard, Deborah A.; Chlenov, Michael; Golembieski, Jeannette; Hornby, Geoffrey; Schechter, Lee E.; Smith, Deborah L.; Andree, Terrance H.; Stack, Gary P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3117 - 3121
