1: 21.1 g / pyridine / 1 h / 40 °C
2: 100 percent / phosphoryl trichloride, N,N-dimethylaniline / 0.12 h / 115 °C
3: 87 percent / triethylamine / methanol / 0.5 h / Ambient temperature
4: 97 percent / ammonia / methanol / Ambient temperature
5: 84 percent / toluene-4-sulphonic acid monohydrate / tetrahydrofuran / 1 h / 50 °C
6: 88 percent / 3-chloroperbenzoic acid / CH2Cl2 / 2.5 h / -5 °C
7: 70 percent / N,N-di-isopropylethylamine / N,N-dimethyl-acetamide / 28 h / 70 - 75 °C
8: 0.65 g / aq. formic acid / 3 h / Ambient temperature
9: hydrogen / palladium on carbon / ethanol; acetic acid; H2O / 2 h
View Scheme
参考文献
Buck, Ildiko M.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 2937 - 2942
Middleton, Richard J.; Briddon, Stephen J.; Cordeaux, Yolande; Yates, Andrew S.; Dale, Clare L.; George, Michael W.; Baker, Julian G.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 782 - 793
