horseradish peroxidase type VI; dihydrogen peroxide T=25°C; pH=7; aq. phosphate bufferEnzymatic reaction;

sodium hydrogencarbonate in dichloromethane; water

1: (NH4)2SO4 / 110 °C 2: 2.) LiAlH4 / 1.) THF, -45 deg C - 60 deg C, 2.) 60 deg C, 10 min View Scheme

1: 48 percent / KOH; NaBH3CN / methanol 2: 68 percent / POCl3 / 4 h / 100 °C 3: m-CPBA; TFA / CH2Cl2 / 2 h / 5 - 20 °C 4: conc. HCl / methanol / 2 h 5: 99 percent / H2 / 10 percent Pd/C / ethanol / 5 h / 760 Torr View Scheme