2-(3-溴苯氧基)四氢-2H-吡喃合成路线 （共 10 条）
反应条件
4-(dimethylamino)pyridinium tosylate in dichloromethane T=20°C; 3 h;
参考文献
Liao, Chien-Tung; Liu, Jung-Yo; Zou, Sing-Fang; Wu, Nien-Chieh; Wu, Zheng-Long; Lee, Jiunn-Yih
Journal of the Chinese Chemical Society, 2010 , vol. 57, # 1 p. 124 - 133
反应条件
in tetrahydrofuran 0.05 h; Reflux; Thermodynamic data;
参考文献
Ende, David J.; Clifford, Pamela J.; Deantonis, David M.; Santamaria, Charles; Brenek, Steven J.
Organic Process Research and Development, 1999 , vol. 3, # 5 p. 319 - 329
反应条件
1: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 10 h 2: conc. aq. HCl / methanol / 0.5 h / 60 - 70 °C View Scheme
参考文献
Ende, David J.; Clifford, Pamela J.; Deantonis, David M.; Santamaria, Charles; Brenek, Steven J.
Organic Process Research and Development, 1999 , vol. 3, # 5 p. 319 - 329
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=20°C; 12 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Liao, Chien-Tung; Liu, Jung-Yo; Zou, Sing-Fang; Wu, Nien-Chieh; Wu, Zheng-Long; Lee, Jiunn-Yih
Journal of the Chinese Chemical Society, 2010 , vol. 57, # 1 p. 124 - 133
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, reflux, 24 h
2: etheral HCl
View Scheme
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
1: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 10 h
2: conc. aq. HCl / methanol / 0.5 h / 60 - 70 °C
View Scheme
参考文献
Foster; Jarman; Leung; McCague; Leclercq; Devleeschouwer
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1491 - 1497
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, reflux, 24 h
2: etheral HCl
View Scheme
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, reflux, 24 h
2: etheral HCl
View Scheme
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C
1.2: 12 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 5 h / 90 °C
3.1: toluene-4-sulfonic acid / methanol; dichloromethane; water / 50 °C
View Scheme
参考文献
Liao, Chien-Tung; Liu, Jung-Yo; Zou, Sing-Fang; Wu, Nien-Chieh; Wu, Zheng-Long; Lee, Jiunn-Yih
Journal of the Chinese Chemical Society, 2010 , vol. 57, # 1 p. 124 - 133
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C
1.2: 12 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 5 h / 90 °C
3.1: toluene-4-sulfonic acid / methanol; dichloromethane; water / 50 °C
View Scheme
参考文献
Liao, Chien-Tung; Liu, Jung-Yo; Zou, Sing-Fang; Wu, Nien-Chieh; Wu, Zheng-Long; Lee, Jiunn-Yih
Journal of the Chinese Chemical Society, 2010 , vol. 57, # 1 p. 124 - 133
