2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
triethylamine in acetone
Ambient temperature;
参考文献
Ukrainets, Igor V.; Bezugly, Peter A.; Treskach, Vladimir I.; Taran, Svetlana G.; Gorokhova, Olga V.
Tetrahedron, 1994 , vol. 50, # 34 p. 10331 - 10338
反应条件
1: 78.5 percent / 2 h / 180 - 210 °C
2: 95.2 percent / POCl3, N,N-dimethylaniline / Heating
3: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C
4: 96.4 percent / dimethylformamide / 14 h / 95 °C
View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
参考文献
WiSys Technology Foundation
Patent: US2010/261711 A1, 2010 ;
反应条件
0.233333 h; Microwave irradiation;
参考文献
Plescia, Salvatore; Raffa, Demetrio; Plescia, Fabiana; Casula, Giovanni; Maggio, Benedetta; Daidone, Giuseppe; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Bombieri, Gabriella; Meneghetti, Fiorella
Arkivoc, 2010 , vol. 2010, # 10 p. 163 - 177
参考文献
Malamas, Michael S.; Millen, Jane
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1492 - 1503
反应条件
1: 1.) NaNO2(aq.), HCl(conc.), 2.) CuBr / 1.)5 deg C, 1 h, 2.) 3 h
2: 96 percent / CuO, K2CO3 / 3 h / 130 °C
View Scheme
参考文献
Khalifa; Osman; Ibrahim; el Rahman; Ossman; Ismail
Pharmazie, 1982 , vol. 37, # 2 p. 115 - 117
反应条件
1: 83 percent / KI / various solvent(s) / 4.5 h / 150 °C
2: dimethylformamide / 20 h / Heating
3: 70 percent / 50percent H2SO4 / acetic acid / 1.5 h / Heating
View Scheme
参考文献
LeMahieu; Carson; Welton; Baruth; Yaremko
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 107 - 110
反应条件
1: 2-amino-5-bromo-benzoic acid With hydrogenchloride in water
8 h;
2: nitromethane With hydrogenchloride; sodium hydroxide in water
T=20°C; 18 h;
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; ZAHLER, Robert; SAHU, Bichismita; AGARWAL, Veena, R.; NAIK, Nishigandha
Patent: WO2012/7926 A1, 2012 ;
Location in patent: Page/Page column 47 ;
WO 2012/007926 A1
反应条件
1: hydrogenchloride / water / 24 h / 20 °C
2: 24 h / 20 °C
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
参考文献
Dolzhenko; Korkodinova; Kotegov; Vasilyuk; Novikova
Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 8 p. 418 - 420
