2-氨基-5-溴苯甲酸合成路线 （共 139 条）
参考文献
Journal of the American Chemical Society, , vol. 32, p. 772
参考文献
Journal of the American Chemical Society, , vol. 32, p. 772
反应条件
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water; N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2012/13643 A1, 2012 ;
Location in patent: Page/Page column 43 ;
反应条件
1: 2-bromo-pyridine; n-butyllithium in diethyl ether; hexane T=-40°C; 1.5 h; 2: 2-amino-5-bromo-benzoic acid in tetrahydrofuran; diethyl ether; hexane T=0°C; 2 h; 3: With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane more than 3 stages;
参考文献
CeNes Limited
Patent: EP1183243 B1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran T=-40°C; 2: 2-amino-5-bromo-benzoic acid in tetrahydrofuran T=0°C;
参考文献
WISYS TECHNOLOGY FOUNDATION, INC.
Patent: US2006/3995 A1, 2006 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1.1: hydrogenchloride; sodium hydroxide; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere 1.2: 0.83 h / 35 - 90 °C / Inert atmosphere 2.1: sulfuric acid / Reflux; Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 67, # 1 p. 125 - 143
反应条件
1: With NOBF4 in dichloromethane; acetonitrile T=-30 - 20°C; Inert atmosphere; 2: With potassium iodide in dichloromethane; acetonitrile T=20°C; Inert atmosphere;
参考文献
Ravnsbaek, Jens B.; Jacobsen, Mikkel F.; Rosen, Christian B.; Voigt, Niels V.; Gothelf, Kurt V.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 46 p. 10851 - 10854
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite Diazotization.weiteres Reagens: wss. Salzsaeure;
参考文献
Acheson; Robinson
Journal of the Chemical Society, 1953 , p. 232,236
反应条件
1: pyridine / 3 h / 0 - 20 °C 2: pyridine; hydrazine hydrate / 0.33 h / 100 °C View Scheme
参考文献
Pandey, Shradha; Singh, Pravin K.; Siddiqui; Singh, Jagdamba
Journal of the Indian Chemical Society, 2011 , vol. 88, # 6 p. 835 - 839
反应条件
in tetrahydrofuran T=-78 - 0°C; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 18 p. 5015 - 5017
