反应条件
1: 4-DMAP, Et3N / CH2Cl2 / 0.17 h / 0 °C 2: 1.) PCl5, pyridine, 2.) butane-1,3-diol / 1.) CH2Cl2, a.) -20 deg C, 15 min, b.) RT, 1.5 h, 2.) CH2Cl2, -20 to RT, 1 h 3: CH2Cl2 / 1 h / Ambient temperature 4: 1.) TFA, anisole, 2.) NH4OH / 1.) RT, 1 h View Scheme
参考文献
Arnould; Bertrandie; Bird; Boucherot; Jung; Lohmann; Olivier; Bailey; Bell; Davies
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2631 - 2642