反应条件
1: 69.9 percent / POCl3 / 3 h / Heating
2: 91.1 percent / H2O / 3 h / Heating
3: 1.) NaNO2, AcOH, 2.) 35percent HNO3 / 1.) H2O, 5 deg C, 1.5 h, 2.) a) 5 deg C, 0.5 h, b) reflux, 1 h
4: Fe, HCl / ethanol; H2O / 0.5 h / Heating
5: 1.) NaNO2, AcOH, 2.) NaN3 / 1.) H2O, 4 deg C, 3 min, 2.) H2O, 2-4 deg C, 10 min
View Scheme
参考文献
Nathanson; Kaugars
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1795 - 1799
