4-溴-2-氟苯甲醛合成路线

参考文献

ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 29 ;

参考文献

Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M.J.M.; Menard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1284 - 1304

67-56-1甲醇+

57848-46-14-溴-2-氟苯甲醛

43192-33-24-溴-2-甲氧基苯甲醛

参考文献

ALBEMARLE CORPORATION; GIARD, Thierry, J.; MUTTERER, Vincent, L.; DURVAUX, Christophe
Patent: WO2012/9173 A1, 2012 ;
Location in patent: Page/Page column 4 ;

124-41-4甲醇钠+

57848-46-14-溴-2-氟苯甲醛

43192-33-24-溴-2-甲氧基苯甲醛

参考文献

ARRAY BIOPHARMA INC.
Patent: WO2009/158426 A1, 2009 ;
Location in patent: Page/Page column 64-65 ;
WO 2009/158426 A1

57848-46-14-溴-2-氟苯甲醛

202865-64-34-溴-2-氟苯甲醛肟

参考文献

Eli Lilly and Company
Patent: US6670373 B1, 2003 ;
Location in patent: Page column 49 ;
US 6670373 B1

2365-48-2巯基乙酸甲酯+

57848-46-14-溴-2-氟苯甲醛

360576-01-86-溴苯并噻吩-2-羧酸甲酯

参考文献

NOVARTIS AG; BOCK, Mark Gary; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2012/149413 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/149413 A1

360576-01-86-溴苯并噻吩-2-羧酸甲酯

参考文献

Zuckerman, Nathaniel B.; Kang, Xiongwu; Chen, Shaowei; Konopelski, Joseph P.
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1482 - 1485

57848-46-14-溴-2-氟苯甲醛

360576-01-86-溴苯并噻吩-2-羧酸甲酯

参考文献

Luithle, Joachim; Bob, Frank-Gerhard; Erb, Christina; Schnizler, Katrin; Flessner, Timo; Kampen, Marja van; Methfessel, Christoph
Patent: US2007/37844 A1, 2007 ;
Location in patent: Page/Page column 7 ;
US 20070037844 A1

57848-46-14-溴-2-氟苯甲醛

259750-61-31-(4-溴-2-氟苯基)丙烷-1-酮

参考文献

Sato Pharmaceutical Co., Ltd.; NAGAI Keita; NAGASAWA Koh; TAKAHASHI Hirobumi; BABA Motoaki; FUJIOKA Shinichi; KONDOH Eri; TANAKA Kenichi; ITOH Yoshiki
Patent: EP2669270 A1, 2013 ;

107-21-1乙二醇+

57848-46-14-溴-2-氟苯甲醛

248270-23-72-(4-溴-2-氟苯基)-1,3-二氧戊环

参考文献

MERCK and CO., INC.; ATON PHARMA, INC.
Patent: WO2006/115835 A2, 2006 ;
Location in patent: Page/Page column 47 ;