1,3-二碘-5-硝基苯合成路线 （共 14 条）
反应条件
1.1: sodium dithionit / H2O; 2-methoxy-ethanol / 3 h / Heating 1.2: 94 percent / conc. HCl / H2O; 2-methoxy-ethanol / 1 h / Heating View Scheme
参考文献
Hoeger; Bonrad; Mourran; Beginn; Moeller
Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5651 - 5659
反应条件
1: With sodium dithionite in 2-methoxy-ethanol; water 3 h; Heating; 2: With hydrogenchloride in 2-methoxy-ethanol; water 1 h; Heating; Further stages.;
参考文献
Hoeger; Bonrad; Mourran; Beginn; Moeller
Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5651 - 5659
反应条件
ethanol; sulfuric acid; sodium nitrite
T=60 - 90°C; 3 h; Cooling with iceInert atmosphere;
参考文献
Goerl, Christian; Beck, Nadine; Kleiber, Katharina; Alt, Helmut G.
Journal of Molecular Catalysis A: Chemical, 2012 , vol. 352, p. 110 - 127
反应条件
sulfuric acid; sodium nitrite
T=0 - 20°C; 0.055 h;
参考文献
Hoeger; Bonrad; Mourran; Beginn; Moeller
Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5651 - 5659
反应条件
sulfuric acid; sodium nitrite in ethanol; chloroform; acetic acid
参考文献
Merck and Co., Inc.
Patent: US5256777 A1, 1993 ;
反应条件
sulfuric acid; sodium nitrite in ethanol; acetic acid
参考文献
Merck and Co., Inc.
Patent: US5292879 A1, 1994 ;
反应条件
1: 50 percent / iodomonochloride / 1,2-dichloro-ethane / 3 h / 70 °C
2: 71 percent / NaNO2; conc. sulfuric acid / 0.06 h / 0 - 20 °C
View Scheme
参考文献
Hoeger; Bonrad; Mourran; Beginn; Moeller
Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5651 - 5659
反应条件
1.1: 74 percent / ICl / acetic acid / Heating
2.1: NaNO2; aq. H2SO4 / 2 h / 0 °C
2.2: 3.2 g / CuSO4*5H2O; EtOH / Heating
View Scheme
参考文献
Ten Brink, Gerd-Jan; Vis, J.Martijn; Arends, Isabel W.C.E; Sheldon, Roger A
Tetrahedron, 2002 , vol. 58, # 20 p. 3977 - 3983
反应条件
copper in N,N-dimethyl-formamide
10 h; Heating;
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Hashino, Hiromi; Kimura, Naoko; Ibuki, Eiichi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 7 p. 2313 - 2320
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Kikutake, Jun-ichiro; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1572 - 1581
