caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=80°C; 6 h; Inert atmosphere;

1: 2-chloro-5-carboxybenzene With Merriefield resin; caesium carbonate in 1-methyl-pyrrolidin-2-one T=200°C; 0.0833333 h; microwave irradiation; 2: (3-methoxyphenyl)zinc(II) iodide With tris(dibenzylideneacetone)dipalladium (0); tBuP*HBF4 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=175°C; Negishi cross-coupling; 0.166667 h; microwave irradiation; 3: With trifluoroacetic acid in dichloromethane T=160°C; 0.0833333 h; microwave irradiation;

sodium hydroxide in tetrahydrofuran 2 h; Ambient temperature;

1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH 2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH 2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature View Scheme

water in methanol T=30 - 50°C; ΔH(excit), ΔS(excit), log A; Rate constantThermodynamic dataKinetics;

(i) (diazotization), (ii) /BRN= 1072099/, aq. NaOH, (iii) aq. KOH, MeOH; Multistep reaction;