4-羟基-2-甲基苯甲酸合成路线 （共 37 条）
反应条件
boron tribromide in dichloromethane T=20°C; 5 h;
参考文献
Lang, Martin; Muehlbauer, Andrea; Graef, Claudia; Beyer, Juergen; Lang-Fugmann, Susanne; Polborn, Kurt; Steglich, Wolfgang
European Journal of Organic Chemistry, 2008 , # 5 p. 816 - 825
反应条件
1: With pyridine in ethyl acetate T=20 - 70°C; 1 h; 2: With sodium hydroxide in water 1 h; Heating / reflux;
参考文献
Assens, Jean-Louis; Bernhart, Claude; Cabanel-Haudricourt, Frederique; Gautier, Patrick; Nisato, Dino
Patent: US2003/225100 A1, 2003 ;
Location in patent: Page 16 ;
反应条件
copper; β-cyclodextrin in potassium hydroxide T=80°C; 15 h;
参考文献
Journal of the American Chemical Society, , vol. 106, # 1 p. 174 - 178
反应条件
1: iodine 2: aq.-ethanolic NaOH-solution View Scheme
参考文献
Journal of the American Chemical Society, , vol. 67, p. 2089,2090
反应条件
sodium hydroxide; copper T=80°C; 5 h;
参考文献
Gaonkar, A. V.; Kirtany, J. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 8 p. 800 - 801
反应条件
hydrogen bromide in acetic acid Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 859 - 866
反应条件
1: 60 percent / Jones' reagent 2: 60 percent / BBr3 / CH2Cl2 / Ambient temperature; or with HBr-HOAc and pyridine-HCl in 20 and 10 percent yield View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, p. 679 - 682
反应条件
1: 40 percent / POCl3 2: 60 percent / Jones' reagent 3: 60 percent / BBr3 / CH2Cl2 / Ambient temperature; or with HBr-HOAc and pyridine-HCl in 20 and 10 percent yield View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, p. 679 - 682
反应条件
1: 52 g / iodine/periodic acid / acetic acid; H2O; H2SO4 / 6 h 2: 1.) butyl-lithium / 1.) ether/hexane, -70 deg C, 45 min; 2.) ether/hexane 3: hydrobromic acid / aq. acetic acid / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 859 - 866
反应条件
1: 1.) butyl-lithium / 1.) ether/hexane, -70 deg C, 45 min; 2.) ether/hexane 2: hydrobromic acid / aq. acetic acid / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 859 - 866
