4-氯-2,5-二氟硝基苯合成路线 （共 6 条）
反应条件
1: 80 percent / triethylamine / Ambient temperature 2: 97 percent / triethylamine / 60 °C View Scheme
参考文献
Hubschwerlen; Pflieger; Specklin; Gubernator; Gmunder; Angehrn; Kompis
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1385 - 1392
反应条件
1: 80 percent / triethylamine / Ambient temperature 2: 93 percent / triethylamine / 60 °C 3: 85 percent / KOH / methanol; H2O / 3 h / 80 °C View Scheme
参考文献
Hubschwerlen; Pflieger; Specklin; Gubernator; Gmunder; Angehrn; Kompis
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1385 - 1392
反应条件
potassium fluoride; dimethyl sulfoxide T=175°C;
参考文献
Finger; Kruse
Journal of the American Chemical Society, 1956 , vol. 78, p. 6034,6037
反应条件
sulfuric acid; potassium nitrate
T=0 - 20°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/36718 A2, 2007 ;
Location in patent: Page/Page column 44 ;
WO 2007/036718 A2
反应条件
sodium hydroxide; conc. HNO3; sulfuric acid in water
参考文献
CENTRO MARGA PARA LA INVESTIGACION S.A.
Patent: EP430847 A1, 1991 ;
反应条件
1: 80 percent / triethylamine / Ambient temperature
2: 93 percent / triethylamine / 60 °C
3: 85 percent / KOH / methanol; H2O / 3 h / 80 °C
4: 0.86 percent / NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature
5: 93 percent / H2 / 5percent Pd/C / methanol
6: 15.5 percent / dimethylformamide / 1.5 h / 50 °C
7: 317 mg / H2O; ethanol / 72 h / 50 °C
8: 61 percent / DBU / tetrahydrofuran / 2 h / 60 °C
9: 72 percent / H2 / 10percent Pd/C / ethanol
10: 58 percent / TFA / 2 h / Ambient temperature
View Scheme
参考文献
Hubschwerlen; Pflieger; Specklin; Gubernator; Gmunder; Angehrn; Kompis
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1385 - 1392
