5-羟基-2-甲基苯甲酸合成路线 （共 26 条）
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: in water 0.5 h; Reflux;
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
AlCl3 in dichloromethane
反应条件
1: With sulfuric acid in water T=160°C; 2.5 h; 2: With potassium hydroxide T=190°C; 2.5 h; 3: With hydrogenchloride in water
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
参考文献
Journal of the American Chemical Society, , vol. 96, p. 2121 - 2129
反应条件
potassium hydroxide; sodium hydroxide T=210 - 220°C; 2.5 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 5 p. 577 - 585
反应条件
1: CF3CO2H 2: aq. NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 96, p. 2121 - 2129
反应条件
sodium hydroxide T=260°C;
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 148
反应条件
sodium hydroxide T=260°C;
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 148
反应条件
sodium hydroxide T=260°C; unter Druck;
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 148
反应条件
potassium hydroxide T=250°C;
参考文献
Pharmaceutical Bulletin, , vol. 2, p. 359,365
