4-甲氧基-1,3-苯并二氧戊环-5-甲醛合成路线 （共 19 条）
反应条件
1: 98 percent / H2 / 5percent Pd-C / ethanol 2: 99 percent / H2 / 5percent Pd-C / ethanol 3: 78 percent / 6N HCl 4: 99 percent / CH2Cl2 / 1 h / Ambient temperature 5: 95 percent / H2 / 5percent Pd-C / ethanol / 7 h / 50 °C 6: I2, potassium acetate / ethanol / 3 h / Heating View Scheme
参考文献
Mao, Yongjun; Song, Shuai; Zhao, Dongmei; Cheng, Maosheng
Heterocycles, 2013 , vol. 87, # 12 p. 2633 - 2640
反应条件
hydrogenchloride in dichloromethane
6 h;
参考文献
Adesomoju; Davis; Rajaraman; et al.
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3220 - 3222
参考文献
Brown, Eric; Loriot, Michel; Robin, Jean-Pierre
Tetrahedron Letters, 1982 , vol. 23, # 9 p. 949 - 952
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Anwar, Hany F.; Hansen, Trond Vidar
Synlett, 2008 , # 17 p. 2681 - 2683
反应条件
potassium carbonate in acetone
4 h; Reflux;
参考文献
Vshyvenko, Sergey; Scattolon, Jon; Hudlicky, Tomas; Romero, Anntherese E.; Kornienko, Alexander
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4750 - 4752
反应条件
trichlorophosphate
1.) 35-38 deg C, 5 h, 2.) 50 deg C, 1.5 h; Yield given. Title compound not separated from byproducts;
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Imaki, Naoshi
Synthetic Communications, 1990 , vol. 20, # 8 p. 1213 - 1221
参考文献
Wagner et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4983,4986
Full Text Show Details
Brownell; Weston
Journal of the American Chemical Society, 1951 , vol. 73, p. 4971
反应条件
potassium carbonate; copper(II) oxide
T=100°C; 4.5 h;
参考文献
Simig, Gy.; Schlosser, M.
ACH - Models in Chemistry, 1994 , vol. 131, # 2 p. 217 - 228
反应条件
1: 94 percent / CuI / methanol / 16 h / Heating
2: 92 percent / aq. 10percent HCl / CH2Cl2 / 6 h
View Scheme
参考文献
Adesomoju; Davis; Rajaraman; et al.
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3220 - 3222
反应条件
1.1: methanol / 1 h / 50 - 60 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -10 - -5 °C / |Inert atmosphere
2.2: 1 h / -10 - -5 °C
3.1: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 60 - 70 °C
4.1: hydrogenchloride / water; dichloromethane / 4 h / 20 °C
View Scheme
参考文献
Mao, Yongjun; Song, Shuai; Zhao, Dongmei; Cheng, Maosheng
Heterocycles, 2013 , vol. 87, # 12 p. 2633 - 2640
