1,2-苯并异恶唑-3-甲酸乙酯合成路线 （共 9 条）
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in ethanol T=0°C; 1 h;
参考文献
Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok
Patent: US2005/250808 A1, 2005 ;
Location in patent: Page/Page column 40 ;
US 20050250808 A1
反应条件
sodium hydride in N,N-dimethyl-formamide T=130°C; 8.41667 h;
参考文献
GENENTECH, INC.
Patent: WO2006/69063 A1, 2006 ;
Location in patent: Page/Page column 88-89 ;
WO 2006/069063 A1
反应条件
in diethylene glycol dimethyl ether; water
反应条件
1: H2SO4 / toluene / Heating 2: isoamyl nitrite, NaOEt / ethanol 3: NaH / bis-(2-methoxy-ethyl) ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 15 p. 2308 - 2314
反应条件
1: isoamyl nitrite, NaOEt / ethanol 2: NaH / bis-(2-methoxy-ethyl) ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 15 p. 2308 - 2314
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=60°C; 1 h; 2: With methanol in tetrahydrofuran
参考文献
GALDERMA RESEARCH and DEVELOPMENT
Patent: US2012/323006 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: H2SO4 2: HNO3, H2SO4 View Scheme
参考文献
Kemp,D.S.; Paul,K.G.
Journal of the American Chemical Society, 1975 , vol. 97, p. 7305 - 7312
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
1.1: sulfuric acid / 48 h / 65 °C
2.1: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
View Scheme
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
