5-溴甲基-3-甲基-1H-吡咯-2,4-二羧酸二乙酯合成路线 （共 18 条）
反应条件
1: 50 percent / aq. HBr / methanol / 7 h / Heating 2: NaOH / ethanol; H2O / 3 h / Heating 3: 120 h / 210 - 220 °C View Scheme
参考文献
Byun; Lightner
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1683 - 1692
反应条件
24 h; Heatingother (α-halomethyl)pyrroles; other symmetrically substituted methylbenzenes; various solvents;
参考文献
Cocco, Domenico; Giancaspro, Carlo; Monaci, Anna; Sleiter, Giancarlo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5217 - 5220
参考文献
Fischer; Scheyer
Justus Liebigs Annalen der Chemie, 1923 , vol. 434, p. 251
反应条件
bromine in acetic acid
T=40 - 43°C; 0.5 h;
参考文献
Byun; Lightner
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1683 - 1692
反应条件
bromine in tetrachloromethane
T=30°C; effect of light; var. molar ratio Br2:pyrrole; MechanismKineticsProduct distribution;
参考文献
Angelini, Giancarlo; Giancaspro, Carlo; Illuminati, Gabriello; Sleiter, Giancarlo
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1786 - 1790
反应条件
1: 1) NaNO2, CH3COOH, 2) Zn, CH3COOH / 1) H2O, < 5 deg C, 1 h, then rt, 1 h, 2) reflux, 2 h
2: 42 percent / bromine / acetic acid / 0.5 h / 40 - 43 °C
View Scheme
参考文献
Byun; Lightner
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1683 - 1692
反应条件
bromine; acetic acid; Petroleum ether
参考文献
Treibs; Bader
Justus Liebigs Annalen der Chemie, 1959 , vol. 627, p. 182,192
参考文献
Fischer; Schormueller
Justus Liebigs Annalen der Chemie, 1929 , vol. 473, p. 211,234
Full Text Show Details
Fischer; Halbig
Justus Liebigs Annalen der Chemie, 1926 , vol. 447, p. 126,137
Justus Liebigs Annalen der Chemie, 1926 , vol. 448, p. 199
参考文献
Fischer; Scheyer
Justus Liebigs Annalen der Chemie, 1923 , vol. 434, p. 251
参考文献
Fischer; Ernst
Justus Liebigs Annalen der Chemie, 1926 , vol. 447, p. 158
