(1-苄基吡咯烷-2-基)甲胺合成路线 （共 13 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; 5 h;
参考文献
Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro
Patent: US2011/237590 A1, 2011 ;
Location in patent: Page/Page column 112 ;
US 20110237590 A1
反应条件
1: H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr
2: CH2Cl2; methanol / 16 h
3: 1.) LiAlH4, 2.) aq. KOH / tetrahydrofuran / 16 h
View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
1: N-methylmorpholine / CH2Cl2 / 2 h / -20 - -15 °C
2: NH3(gas) / CH2Cl2 / 1 h / -20 °C
3: H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr
4: CH2Cl2; methanol / 16 h
5: 1.) LiAlH4, 2.) aq. KOH / tetrahydrofuran / 16 h
View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
1: sodium tris(acetoxy)borohydride / toluene / 24 h / 20 °C / Cooling with ice
2: triethylamine / chloroform / 0.5 h / Cooling with ice
3: sodium azide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
4: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C
View Scheme
参考文献
Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro
Patent: US2011/237590 A1, 2011 ;
US 20110237590 A1
反应条件
1: sodium tris(acetoxy)borohydride / toluene / 24 h / 20 °C / Cooling with ice
2: triethylamine / chloroform / 0.5 h / Cooling with ice
3: sodium azide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
4: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C
View Scheme
参考文献
Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro
Patent: US2011/237590 A1, 2011 ;
US 20110237590 A1
反应条件
1: triethylamine / chloroform / 0.5 h / Cooling with ice
2: sodium azide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
3: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C
View Scheme
参考文献
Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro
Patent: US2011/237590 A1, 2011 ;
US 20110237590 A1
反应条件
1: sodium azide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
2: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C
View Scheme
参考文献
Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro
Patent: US2011/237590 A1, 2011 ;
US 20110237590 A1
反应条件
potassium hydroxide; lithium aluminium tetrahydride in tetrahydrofuran
16 h; Yield given;
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
1: 1.) aq. HCl, 2.) conc. H2SO4 / 2.) reflux, 16 h
2: NH3(gas) / methanol / 40 h / 80 °C
3: 1.) LiAlH4, 2.) aq. KOH / tetrahydrofuran / 16 h
View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
1: NH3(gas) / methanol / 40 h / 80 °C
2: 1.) LiAlH4, 2.) aq. KOH / tetrahydrofuran / 16 h
View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
