4-氨基-3-氯-5-硝基三氟甲苯合成路线 (共 4 条)
反应条件
ammonium hydroxide 0.5 h;
参考文献
Collins; McFarlane; Mackie; Smith
Tetrahedron, 1992 , vol. 48, # 37 p. 7887 - 7898
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine; sulfuric acid; nitric acid; 2-amino-5-(trifluoromethyl)-1,3,4-thiadiazole 1.) RT, 120 h, 2.) reflux, 85 h; Yield given. Yields of byproduct given;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 247 - 253
反应条件
hydrogenchloride; sulfuric acid; sodium nitrite in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
参考文献
Altmann, Karl-Heinz; Bold, Guido; Manley, Paul William
Patent: US2002/10181 A1, 2002 ;
反应条件
palladium on activated charcoal in ethanol; cyclohexene 1.2 h; Heating;
参考文献
Collins; McFarlane; Mackie; Smith
Tetrahedron, 1992 , vol. 48, # 37 p. 7887 - 7898