4-溴-N-(2-羟基乙基)苯羧胺合成路线 (共 8 条)
反应条件
sodium methylate T=70°C; 1 h;
参考文献
Hiraoka, Shuichi; Tanaka, Takaaki; Shionoya, Mitsuhiko
Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13038 - 13039
反应条件
1: 4-bromophenylacetic acid With N-ethyl-N,N-diisopropylamine; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride in dichloromethane T=20°C; 0.166667 h; 2: ethanolamine in dichloromethane T=20°C; 1 h; 3: With hydrogenchloride in dichloromethane; water T=20°C;
参考文献
WO2006/64251 A1, ;
Page/Page column 65 ;
WO 2006/064251 A1
反应条件
N(Et)4ClO4 in acetonitrile T=23°C;
参考文献
Arai, Kenji; Shaw, Chu-hei; Nozawa, Koohei; Kawai, Ken-ichi; Nakajima, Shoichi
Tetrahedron Letters, 1987 , vol. 28, # 4 p. 441 - 442
反应条件
1: H2SO4 / 8 h / Heating 2: CHCl3 / 8 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 6 p. 808 - 816
反应条件
acid buffer (formate pH 3.4-3.7) in acetonitrile T=25°C; var. pH (from neutral to 2.0); Rate constant;
参考文献
Journal of Organic Chemistry, , vol. 52, # 5 p. 805 - 808
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 24 p. 6486 - 6489
反应条件
1: DMAP; Et3N / CH2Cl2 / 20 h / 20 °C 2: 85 percent / NaOH / methanol / 2 h / 20 °C View Scheme
参考文献
Hiraoka, Shuichi; Tanaka, Takaaki; Shionoya, Mitsuhiko
Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13038 - 13039
反应条件
zinc trifluoromethanesulfonate; carbonic acid diethyl ester 45 h; Inert atmosphereRefluxSolvolysis;
参考文献
Kita, Yusuke; Nishii, Yuji; Higuchi, Takafumi; Mashima, Kazushi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 23 p. 5723 - 5726