(4-甲氧基苯基)-哌啶-1-基甲酮合成路线 （共 40 条）
反应条件
1: 83 percent / LiAlH4 / diethyl ether / Heating 2: 1.) vinyl chloroformate, 2.) HCl / 1.) CH2Cl2, 0 deg C to room temperature;reflux, 4 h, 3.) MeOH, 50-60 deg C, 4.5 h View Scheme
参考文献
Howarth, Nicola M.; Malpass, John R.; Smith, Craig R.
Tetrahedron, 1998 , vol. 54, # 36 p. 10899 - 10914
反应条件
trichloromonobromomethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine in tetrahydrofuran; dichloromethane
T=60°C; 6 h; Inert atmosphere;
参考文献
Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 19 p. 3971 - 3977
反应条件
N,N,N',N,-tetramethylethylenediamine; di-(1-adamantyl)-n-butylphosphine; palladium diacetate in toluene
T=115°C; P=26252.1 Torr; 16 h;
参考文献
Neumann, Helfried; Brennfuehrer, Anne; Gross, Peter; Riermeier, Thomas; Almena, Juan; Beller, Matthias
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1255 - 1261
反应条件
in dichloromethane
T=20°C; 2 h;
参考文献
Wu, Xianglong; Fan, Wutu; Pan, Yalei; Zhai, Yuankun; Niu, Yinbo; Li, Chenrui; Mei, Qibing
Molecules, 2014 , vol. 19, # 1 p. 1034 - 1046
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Xie, Weilong; Zhao, Mengdi; Cui, Chunming
Organometallics, 2013 , vol. 32, # 24 p. 7440 - 7444
反应条件
air; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium diacetate in tetrahydrofuran
T=100°C; 0.25 h; mocrowaver irradiation;
参考文献
Wannberg, Johan; Larhed, Mats
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5750 - 5753
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Cacchi, Sandro; Ciattini, Pier Giuseppe; Morera, Enrico; Ortar, Giorgio
Tetrahedron Letters, 1986 , vol. 27, # 33 p. 3931 - 3934
反应条件
sodium carbonate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) in water
T=170°C; 0.166667 h; microwave irradiation;
参考文献
Wu, Xiongyu; Larhed, Mats
Organic Letters, 2005 , vol. 7, # 15 p. 3327 - 3329
反应条件
copper(l) iodide; oxygen in toluene
T=70°C; P=760.051 Torr; Sealed tube;
参考文献
Zhang, Jian; Liu, Yu; Chiba, Shunsuke; Loh, Teck-Peng
Chemical Communications, 2013 , vol. 49, # 97 p. 11439 - 11441
反应条件
trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane
T=160°C; 0.333333 h; Microwave irradiation;
参考文献
Odell, Luke R.; Saevmarker, Jonas; Larhed, Mats
Tetrahedron Letters, 2008 , vol. 49, # 42 p. 6115 - 6118
