1,3-苯并二噁茂-4-甲酸合成路线 （共 25 条）
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 3.5 h; 2: With hydrogenchloride in methanol; water
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2116538 A1, 2009 ;
Location in patent: Page/Page column 49 ;
反应条件
dihydrogen peroxide; potassium carbonate in methanol; water
参考文献
SmithKline Beecham Corporation
Patent: US6500863 B1, 2002 ;
US 6500863 B1
反应条件
1: With methanol; potassium hydroxide T=20°C; 3 h; 2: With hydrogenchloride in water pH=3.5; Cooling with ice;
参考文献
Huang, Zhiqiang; Liu, Yuxiu; Li, Yongqiang; Xiong, Lixia; Cui, Zhipeng; Song, Hongjian; Liu, Hongli; Zhao, Qiqi; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 2 p. 635 - 644
反应条件
n-butyllithium; sodium hydrogencarbonate in hexane
参考文献
US5886044 A1, ;
US 5886044 A
反应条件
1: Methylenedioxybenzene With sec.-butyllithium in tetrahydrofuran; pentane T=-100°C; 2 h; 2: carbon dioxide in tetrahydrofuran; pentane Further stages.;
参考文献
Chemistry - A European Journal, , vol. 8, # 4 p. 799 - 804
反应条件
1.1: 40 percent / H2SO4 / 24 h / 60 °C 2.1: KF / dimethylformamide / 0.5 h / 20 °C 2.2: 80 percent / dimethylformamide / 3 h / 120 °C 3.1: 73 percent / KOH / methanol; H2O / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
baker's yeast on montmorillonite K10; potassium chloride; [14C]-Sucrose T=35°C; Reduction; Bioreduction; 48 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Patrocinio, Amauri F.; Correa Jr., Ivan R.; Moran, Paulo J. S.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 21 p. 3133 - 3137
反应条件
1: 67 percent / cupric oxide 2: 81 percent / KMnO4 View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 44, # 2 p. 235 - 243
反应条件
1: 49 percent / acid 2: 67 percent / cupric oxide 3: 81 percent / KMnO4 View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 44, # 2 p. 235 - 243
反应条件
1: hydrogen iodide / 100 °C 2: aqueous-alcoholic KOH-solution; hydrogen stream View Scheme
参考文献
Journal of the Chemical Society, , p. 2932
