N-Cbz-顺式-L-羟脯氨酸甲酯合成路线 （共 4 条）
反应条件
1: pyridine 2: 97 percent / LiN3 3: H2S / pyridine 4: DIEA 5: H2 / Pd/C View Scheme
参考文献
Jordan, Stephan; Schwemler, Christoph; Kosch, Winfried; Kretschmer, Axel; Schwenner, Eckhardt; Stropp, Udo; Mielke, Burkhard
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 681 - 686
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid in dichloromethane 18 h; Ambient temperature;
参考文献
Smith, Elisabeth M.; Swiss, Gerald F.; Neustadt, Bernard R.; Gold, Elijah H.; Sommer, Jane A.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 875 - 885
反应条件
1: 1H-imidazole / dichloromethane / 1.5 h / 20 °C 2: lithium borohydride / tetrahydrofuran / 4 h / 0 - 20 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 - 20 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C 5: sodium hydride / tetrahydrofuran / 24 h / 0 - 20 °C 6: palladium 10 on activated carbon; hydrogen / methanol / 50 °C View Scheme
参考文献
YM BIOSCIENCES AUSTRALIA PTY LTD; BURNS, Christopher John
Patent: WO2014/32 A1, 2014 ;
反应条件
lithium borohydride in tetrahydrofuran
参考文献
Ceulemans, G.; Aerschot, A. Van; Herdewijn, P.
Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S234 - S237
