3-(三氟甲基)-1H-吲唑合成路线 （共 10 条）
反应条件
hydrazine in ethanol
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/148832 A1, 2008 ;
Location in patent: Page/Page column 37-38 ;
WO 2008/148832 A1
反应条件
acetic acid; sodium nitrite in water
T=20°C; 72 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
carbon monoxide; pentamethylcyclopentadienyl dicarbonyl iron(II) dimer in 1,4-dioxane
T=150°C; P=38000 Torr; 72 h;
参考文献
O'Dell, David K.; Nicholas, Kenneth M.
Heterocycles, 2004 , vol. 63, # 2 p. 373 - 382
反应条件
1: 63 percent / N2H4*H2O / ethanol / 12 h / Heating
2: 25 percent / Pd/C / decahydronaphthalene / 168 h / Heating
View Scheme
参考文献
Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose
New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946
反应条件
1.1: tetrahydrofuran / 1 h / Heating
1.2: tetrahydrofuran / 18 h / 20 °C
2.1: 63 percent / N2H4*H2O / ethanol / 12 h / Heating
3.1: 25 percent / Pd/C / decahydronaphthalene / 168 h / Heating
View Scheme
参考文献
Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose
New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946
反应条件
palladium on activated charcoal in decalin
168 h; Heating;
参考文献
Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose
New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946
反应条件
1: 45 percent / phenylmagnesium chloride / tetrahydrofuran / 1 h / -40 °C
2: 52 percent / hydroxylamine hydrochloride / ethanol; pyridine / 91 h / Heating
3: CO; pentamethylcyclopentadienyl dicarbonyl iron(II) dimer / dioxane / 72 h / 150 °C / 38000 Torr
View Scheme
参考文献
O'Dell, David K.; Nicholas, Kenneth M.
Heterocycles, 2004 , vol. 63, # 2 p. 373 - 382
反应条件
1: 52 percent / hydroxylamine hydrochloride / ethanol; pyridine / 91 h / Heating
2: CO; pentamethylcyclopentadienyl dicarbonyl iron(II) dimer / dioxane / 72 h / 150 °C / 38000 Torr
View Scheme
参考文献
O'Dell, David K.; Nicholas, Kenneth M.
Heterocycles, 2004 , vol. 63, # 2 p. 373 - 382
反应条件
1: 35 percent / N-bromosuccinimide / acetonitrile / 48 h / 20 °C
2: 86 percent / triethylamine; 4-(dimethylamino)pyridine / acetonitrile / 5 h / 20 °C
View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 48 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
