2-乙基-1H-咪唑-4,5-二甲腈合成路线 （共 5 条）
反应条件
sodium methylate in methanol; methoxybenzene T=100°C;
参考文献
AL-Azmi, Amal; George, Paulson; El-Dusouqui, Osman M.E.
Heterocycles, 2007 , vol. 71, # 10 p. 2183 - 2201
反应条件
sodium hydride in N,N-dimethyl-formamide Heating;
参考文献
Al-Azmi, Amal; George, Paulson; El-Dusouqui, Osman M. E.
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 3 p. 515 - 520
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AL-Azmi, Amal; George, Paulson; El-Dusouqui, Osman M.E.
Heterocycles, 2007 , vol. 71, # 10 p. 2183 - 2201
反应条件
1.) CH3CN, reflux, 5 h, 2.) xylene, reflux, 7 h;
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
参考文献
Yakugaku Zasshi, , vol. 57, p. 1023,1025; dtsch. Ref. 58<1938>1
Chem.Abstr., , p. 3394,3395
反应条件
1: 55 percent / 6N aq. HCl / 8 h / Heating
2: 85 percent / HCl / Ambient temperature
View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
