2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran T=0 - 25°C; Inert atmosphere; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in dichloromethane; perfluorodecahydronaphthalene T=-78 - 25°C; Inert atmosphere;
参考文献
Yamada, Shigeyuki; Knochel, Paul
Synthesis, 2010 , # 14 art. no. T09010SS, p. 2490 - 2494
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; Flow reactor; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; hexane T=0°C; Flow reactor; Reagent/catalyst;
参考文献
Nagaki, Aiichiro; Uesugi, Yuki; Kim, Heejin; Yoshida, Jun-Ichi
Chemistry - An Asian Journal, 2013 , vol. 8, # 4 p. 705 - 708
反应条件
nitric acid; acetic anhydride; acetic acid
参考文献
Fittig; Storer
Justus Liebigs Annalen der Chemie, 1868 , vol. 147, p. 8
反应条件
1.1: Mg; I2 / tetrahydrofuran / 14 h / Heating 1.2: tetrahydrofuran / -78 - 20 °C 2.1: 3.27 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 3.1: 94 percent / Pd(PPh3)4; Ba(OH)2*8H2O / H2O; dioxane / 24 h / Heating View Scheme
参考文献
Wipf, Peter; Jung, Jae-Kyu
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6319 - 6337
反应条件
1: (i) Li, (ii) /BRN= 1636531/ 2: SOCl2 3: Zn / acetic acid View Scheme
参考文献
Albert,K.; Rieker,A.
Chemische Berichte, 1977 , vol. 110, p. 1804 - 1822
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=20°C; Inert atmosphere; 3: 1-phenylethyl 2,2,2-trifluoroacetate With zinc(II) chloride in toluene T=50°C; 24 h; Inert atmosphere;
参考文献
Duan, Hui; Meng, Lingkui; Bao, Denghui; Zhang, Heng; Li, Yao; Lei, Aiwen
Angewandte Chemie - International Edition, 2010 , vol. 49, # 36 p. 6387 - 6390
反应条件
1: With triethylamine; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heck reaction; 2: With hydrogen; palladium in ethanol 3: With N-methyl-2-indolinone; tetrapropylammonium perruthennate in dichloromethane
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
triethylamine; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heck reaction;
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
1: With triethylamine; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heck reaction; 2: With hydrogen; palladium in ethanol Title compound not separated from byproducts;
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
1: NaHCO3 / cis,cis,cis-1,2,3,4-(Ph2PCH2)4-cyclopentane/[PdCl(C3H5)]2 / dimethylformamide / 20 h / 150 °C 2: aq. HCl / tetrahydrofuran / 25 °C View Scheme
参考文献
Battace, Ahmed; Zair, Touriya; Doucet, Henri; Santelli, Maurice
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 459 - 462
