2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
tert.-butyl lithium 2) ether, -78 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 56, # 2 p. 893 - 896
反应条件
n-butyllithium 1) ether, hexanes, 23 deg C, 18 h, 2) -40 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 32, # 47 p. 6835 - 6838
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 1.5 h / -78 °C / Inert atmosphere 2.1: water; sodium hydroxide / methanol / 1 h / 20 - 50 °C View Scheme
参考文献
Watanabe, Nobuko; Hamano, Mitsutaka; Todaka, Shota; Asaeda, Takahiro; Ijuin, Hisako K.; Matsumoto, Masakatsu
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 632 - 639
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; water in dimethyl sulfoxide T=130°C; Domino Suzuki coupling and fragmentation reaction; 16 h; Inert atmosphere;
参考文献
Velcicky, Juraj; Soicke, Arne; Steiner, Roland; Schmalz, Hans-Guenther
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6948 - 6951
反应条件
in diethyl ether N2-atmosphere; addn. of mesityl bromide (in Et2O) to Mg, filtration, cooling to -20°C, addn. of SnCl4 (in light petroleum), stirring (room temp., 15 h), refluxing (2 h); filtration, concentrating, trituration with light petroleum, recrystn. (light petroleum); total yield 30percent; mixt. of products (Cl2:BrCl:Br2 derivative=3:30:67) not sepd., detd. by (119)Sn-NMR spectroscopy;
参考文献
Brown, Paul; Mahon, Mary F.; Molloy, Kieran C.
Journal of Organometallic Chemistry, 1992 , vol. 435, # 3 p. 265 - 273
参考文献
E. I. Du Pont de Nemours and Co.
Patent: US5118880 A1, 1992 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite in toluene T=100°C; P=3750.38 Torr; 20 h; Inert atmosphere;
参考文献
Neumann, Helfried; Kadyrov, Renat; Wu, Xiao-Feng; Beller, Matthias
Chemistry - An Asian Journal, 2012 , vol. 7, # 10 p. 2213 - 2216
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C;
参考文献
Fergus, Suzanne; Eustace, Stephen J.; Hegarty, Anthony F.
Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4663 - 4669
反应条件
magnesium in N,N-dimethyl-formamide byproducts: Mg(2+); Electrolysis; electrolysis carried out in a single-compartment cell at room temp., starting materials dissolved in DMF containing KBr or n-Bu4NBr, solvent andexcess B(OCH3)3 evaporated under vacuum, medium hydrolysed at 0° C with an HCl or H2SO4 soln.; extraction with Et2O (3 x 20 ml if the solvent evaporated or 3 x 60 ml otherwise), organic phase dried over sodium or magnesium sulfate and concentrated under vacuum, side product phenol formation avoided by work-up under inert atmosphere;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
1: With boric acid trimethyl ester T=20°C; Electrochemical reactionMg consumable anode, supporting electrolyte; 2: T=0°C; Acid hydrolysis; Further stages.;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
